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Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
Krahmer et. al., Developmental Cell, 2018
JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis‐like cells
Schwentner et. al., J Leukoc Biol. 2019
Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
Tiwari et. al., Nature Communications, 2018
Effectiveness of EGFR/HER2-targeted drugsis influenced by the downstreaminteraction shifts of PTPIP51 in HER2-amplified breast cancer cells
Dietel et. al., Oncogenesis, 2018
Composition For Targeted Delivery Of Nucleic Acid-Based Therapeutics
Paukshto et. al., United States Patent Application 20180214575, 2018
Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7.
Dennis et. al., Mucosal Immunol., 2018
JNK regulates muscle remodeling via myostatin/SMAD inhibition.
Lessard et. al., Nat Commun. 2018
Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.
Bercusson et. al., Blood., 2018
Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites
Unger et. al., Front. Immunol., 2018
Synthetic mRNA expressed Cas13a mitigates RNA virus infections
et. al. ,
Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.
Weber et. al., Nat Commun., 2018
Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions upon epithelial differentiation.
Noethel et. al., Mol Biol Cell., 2018
GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells.
Chen et. al., Int J Cancer., 2018
Immunostimulatory guide RNAs mediate potent antiviral response
Membrane Fluidity Is Regulated Cell Non-autonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2.
Bodhicharla et. al., Genetics., 2018
Neurodevelopmental protein Musashi–1 interacts with the Zika genome and promotes viral replication.
Chavali et. al., Science., 2017
Expression of AGPAT2, an enzyme involved in the glycerophospholipid / triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.
Triantafyllou et. al., Biochim Biophys Acta., 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler et. al., Cell., 2018
High molecular weight hyaluronic acid: a two-pronged protectant against infection of the urogenital tract?
Mowbray et. al., Clinical & Translational Immunology 2018
Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.
Li et. al., Oncogene., 201
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.
Ringleb et. al., J Immunol., 2018
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Ugolini et.al., Nat Immunol., 2018
The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2
Fuchs et. al., BioRxiv, 2018
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity.
Shin et. al., Mol Ther Nucleic Acids., 2018
CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.
Taylor et. al., J Leukoc Biol., 2018
The 5T4 oncofetal glycoprotein does not act as a general organizer of the CXCL12 system in cancer cells.
Puchert et. al., Exp Cell Res., 2018
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells.
transfections in supplemental data
Xue et. al., Nat Mater., 2018
Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.
Mueller et. al., J Biol Chem., 2018
Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma
Chortis et. al., Endocrinology, 2018
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.
transfections in supplemental data
Anderson et. al., Nat Commun., 2018
Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms.
Leber et. al., Inflamm Bowel Dis. 2018
Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.
Slater et. al., Virol J. 2018
Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection.
Herrera-Uribe et. al., Vet Res., 2018
Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction.
Bhosle et. al., Biomaterials. 2018
Involvement of the oncogene B-cell lymphoma 6 in the fusion and differentiation process of trophoblastic cells of the placenta.
Jasmer et. al., Oncotarget., 2017
Functional characterization of the protein kinase MK2 in the pathogenesis of Experimental autoimmune encephalomyelitis (EAE)
Gupta – 2017
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.
Mathur et. al., Neuron., 2017
RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.
Egami et. al., J Cell Sci., 2017
Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages.
Lin et. al., Cell Syst., 2017
The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids
Devkota et. al., PLoS Genet., 2017
Long 3’UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons.
Pereira et. al., PLoS One., 2017
Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling.
Nishiyama et. al., Int Immunopharmacol., 2017
Dexamethasone-induced upregulation of CaV3.2 T-type Ca2+ channels in rat cardiac myocytes.
Falcón et. al., J Steroid Biochem Mol Biol., 2017
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Van Opdenbosch et. al., Cell Rep., 2017
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Fujita et. al., Nat Commun., 2017
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.
Ambrosio et. al., Oncogene. 2017
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.
Thompson et. al., bioRxiv, 2017
Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase.
Chen et. al., Arterioscler Thromb Vasc Biol., 2017
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat
Long et. al., Sci Rep., 2017
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.
Rübsam et. al., Nat Commun. 2017
Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses
Kim et. al., Adv Healthc Mater., 2017
FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction
Smith et. al., Int J Biochem Cell Biol., 2017
The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages
Lewis – 2017
METHYL CAP BINDING PROTEIN 2 IN SYSTEMIC SCLEROSIS
O’Reilly – 2017
Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation.
Drakouli et. al., FEBS J., 2017
Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection.
Ali et. al., Sci Rep., 2017
The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts.
McCormack et. al., Sci Rep., 2017
CHARACTERIZATION OF IN VITRO TRANSCRIBED MRNA FOR OPTIMAL EXPRESSION IN THERAPEUTIC APPLICATIONS
Kirschman – 2017
The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability.
Shah et. al., Nat Commun., 2017
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
Liszt et. al., Proc Natl Acad Sci U S A., 2017
Angiopoietin-like Protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP
Ingerslev et. al., Mol Metab., 2017
Integrated analysis of miRNA expression in response to Salmonella Typhimurium infection in pigs.
Herrera Uribe – 2017
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.
Brüser et. al., Sci Rep., 2017
The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.
Kijewska et. al., Oncotarget., 2017
Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential.
Walsh et. al., Sci Rep., 2017
Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells.
Kirschman et.al., Nucleic Acids Res., 2017
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.
Armento et. al., Int J Oncol., 2017
Hmga2 translocation induced in skin tumorigenesis.
Li et. al., Oncotarget., 2017
FGF23 is synthesised locally by renal tubules and activates injury–primed fibroblasts.
transfections in supplemental data
Smith et. al., Sci Rep., 2017
The role of microRNA-5196 in the pathogenesis of systemic sclerosis.
Ciechomska et. al., Eur J Clin Invest., 2017
Effects of hypnotic bromovalerylurea on microglial BV2 cells.
Kawasaki et. al., J Pharmacol Sci., 2017
HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors.
Kew et. al., J Mol Biochem., 2017
Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.
Furtado et. al., JCI Insight., 2017
A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB.
Park et. al., Int J Oncol., 2017
Corneal stromal stem cells reduce corneal scarring by mediating neutrophil infiltration after wounding.
Hertsenberg et. al., PLoS ONE, 2017
GANCICLOVIR DERIVATIVES FOR MODULATING INNATE AND ADAPTIVE IMMUNITY AND FOR USE IN IMMUNOTHERAPY
Burai et. al., US Patent 20,170,050,967, 2017
Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.
Czirr et. al., J Exp Med., 2017
The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.
Haneklaus et. al., JBC, 2017
Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia.
Chinthamani et. al., PLoS ONE, 2017
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Diamanti et. al., J Exp Med., 2017
Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial–mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms.
et. al., Cell Death & Differentiation, 2017
Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites.
Muggiolu et. al., Sci Rep., 2017
The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.
Mescher et. al., J Exp Med., 2017
The dual role of asporin in breast cancer progression.
Simkova et.al., Oncotarget., 2016
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.
Morrison et.al., J. Vis. Exp., 2016
Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability.
Hadadi et.al., Sci Rep., 2016
The p7 viroporin of the hepatitis C virus contributes to liver inflammation by stimulating production of Interleukin-1 β.
Farag et. al., Biochim Biophys Acta., 2016
Loss of the Tumor Suppressor NKX3.1 in Prostate Cancer Cells is Induced by Prostatitis Related Mitogens
Decker et.al., J Clin Onc Exp Onc, 2016
Transkriptionsregulation der Pyruvatdehydrogenase – Kinase 4 (PDK4), einem zentralen Schalter des Glukosestoffwechsels, durch Zelladhäsion und onkogene Signalwege beim humanen Ovarialkarzinom
Schnitzer – 2016
Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.
Klingler et.al., Biochim Biophys Acta., 2016
Early Intervention Stem Cell-Based Therapy (EISCBT) for Corneal Burns and Trauma
Funderburgh – 2016
IFN-ε protects primary macrophages against HIV infection.
Tasker et.al., JCI Insight., 2016
BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells.
Ciechomska et.al., Sci Rep., 2016
GSK-3β controls NF-kappaB activity via IKKγ/NEMO.
Medunjanin et.al., Sci Rep., 2016
Defining functional interactions during biogenesis of epithelial junctions
Erasmus et.al., Nat Commun., 2016
Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.
Jung et. al., Sci Signal., 2016
Human Neural Progenitor Cells are Productively Infected by R5-tropic HIV-1: Opiate Interactions on Infection and Function Involve Cdk5 Signaling
JM Balinang – 2016
Donor dendritic cell–derived exosomes promote allograft–targeting immune response.
transfections in supplemental data
Liu et. al., J Clin Invest., 2016
Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease
Kadiyska – 2016
STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Yan et.al., Cell Rep, 2016
Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression.
Ellert-Miklaszewska et. al., Oncogene 2016
Extensive nuclear sphere generation in the human Alzheimer’s brain
Kolbe et. al., NeuroBiolAging, 2016
Ziros et. al., PLoS One., 2016
Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.
Machacek et. al., J Immunol., 2016
Analyse des signalinduzierten Verlusts des Tumorsuppressors NKX3.1 in Prostatitis und Prostatakarzinomzellen
Decker, 2016
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.
Martin-Almedina et. al., J Clin Invest. 2016
HIV-Infected Dendritic Cells Present Endogenous MHC Class II-Restricted Antigens to HIV-Specific CD4+ T Cells.
Coulon et. al., J Immunol., 2016
ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers
Madan et. al., Am J Cancer Re., 2016
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.
Kranz et. al., Nature. 2016
Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization.
Watanabe et. al., Proc Natl Acad Sci U S A., 2016
Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.
Shen et. al., Am J Pathol., 2016
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
Paijo et. al., PLoS Pathog., 2016
microRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.
Griss et. al., J Infect Dis, 2016
Steroidogenesis in Steroid Related Cancers
Turgeman – 2016
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.
Robertson et. al., PLoS Biol, 2016
Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans
Ordelheide et. al., Molecular Metabolism, 2016
Histone demethylation and TLR8-dependent crosstalk in monocytes promotes trans-differentiation of fibroblasts in systemic sclerosis via Fra2.
Ciechomska et.al., Arthritis Rheumatol, 2016
Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.
Yuniati et. al., Oncotarget, 2016
Pathways of retinoid synthesis in mouse macrophages and bone marrow cells.
Niu et. al., J Leukoc Biol, 2016
p53 coordinates base excision repair to prevent genomic instability
Poletto et.al., Nucleic Acids Res, 2016
Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with Influenza A virus
Pichulik et.al., Eur J Immunol, 2015
Hypoxia Differentially Modulates the Genomic Stability of Clinical-Grade ADSCs and BM-MSCs in Long-Term Culture.
Bigot et.al., Stem Cells, 2015
Drug Delivery Using Novel Biological and Synthetic Materials
Ito et. al., Biomed Res Int, 2015
Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.
Chen et. al., Sci Signal., 2015
The Comparative Utility of Viromer RED and Lipofectamine for Transient Gene Introduction into Glial Cells
Rao et.al., Hindawi Publishing Group, BioMed Research International, 2015
Inhibition of adipogenic differentiation of human SGBS preadipocytes by androgen-regulated microRNA miR-375.
Kraus et.al., Mol Cell Endocrinol., 2015
Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.
Rane et.al., Br J Cancer, 2015
TRIM25 has a dual function in the p53/Mdm2 circuit
Zhang et.al., Oncogene, 2015
Weber et.al., 2015
MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity.
Salama et. al., PLoS One, 2014
Vernakalant activates human cardiac K(2P)17.1 background K(+) channels.
Seyler et. al., Biochem Bophys Res Commun., 2014
Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.
Zekavati et. al., PLoS One, 2014
Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking.
Prescott et. al., J Cell Sci., 2014
High-Tech Polymers Leveraging Viral Biophysics Can Enhance the Transfection of Nucleic Acids
Panzner, GEN, 2014