Viromer® transfection publications

Download the new Viromer® table featured publications to get a great overview about the transfection of:

  • immune cells
  • neurons & glioma and neuroblastoma cells
  • fibroblasts
  • keratinocytes
  • hepatic cells
  • muscle cells
  • breast, ovaria and vagina cells
  • stem cells
  • different types of cancer cells like lung carcinoma and sarcoma
  • mRNA transfection
  • shRNA-mediated silencing
  • luciferase assays
Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis.
Hlavac et. al., Cell Oncol (Dordr)., 2019
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.

Sarno et. al., Nucleic Acids Res., 2019

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.

Bianco et. al., Nat Commun., 2019

Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload.

Honda et. al., J Cell Physiol., 2019



Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells.

Was et. al., Clin Epigenetics., 2019

Downregulated Caveolin-1 expression in circulating monocytes may contribute to the pathogenesis of psoriasis.

Takamura et. al., Sci Rep., 2019

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.

Houtman et. al., EMBO J., 2019

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis.

Choi et. al., Nat Microbiol., 2019

Characterization of Cells Interactions with Patterned Azopolymer-Based Materials using SEM, AFM and Video Microscopy

Barillé et. al., The Open Biomedical Engineering Journal, 2018

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Liccardi et. al., Mol Cell., 2019

Impact of Variant Notch Ligandson Chronic Liver Diseases

Dewidar, 2018

Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo.

Xu et. al., J Immunol., 2019

Markers of Accelerated Skeletal Muscle Regenerative Response in Murphy Roths Large Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.

Tseng et. al., Stem Cells., 2019

Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D.

Li et. al., J Biol Chem., 2019

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.

Durré et. al., Nat Commun., 2018

Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer’s disease.

Hu et. al., Brain Pathol., 2019

Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.
Ruiz et. al., Elife., 2018
NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses.
Mirza et. al.J Immunol., 2019
CSAP Acts as a Regulator of TTLL-Mediated Microtubule Glutamylation.
Bompard et. al.Cell Rep., 2018
Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing.
Sanchez-Garrido et. al., Sci Signal., 2018
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.

Fiore et. al., Nat Commun., 2018

Mechanosensorische Prozesse zur Erkennung und Prozessierung zyklischer Dehnungwährend der epithelialen Differenzierung

Noethel, 2018

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

Krahmer et. al., Developmental Cell, 2018

JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis‐like cells

Schwentner et. al., J Leukoc Biol. 2019

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Tiwari et. al., Nature Communications, 2018

Effectiveness of EGFR/HER2-targeted drugsis influenced by the downstreaminteraction shifts of PTPIP51 in HER2-amplified breast cancer cells

Dietel et. al., Oncogenesis, 2018

Composition For Targeted Delivery Of Nucleic Acid-Based Therapeutics

Paukshto et. al., United States Patent Application 20180214575, 2018

Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7.

Dennis et. al., Mucosal Immunol., 2018

JNK regulates muscle remodeling via myostatin/SMAD inhibition.

Lessard et. al., Nat Commun. 2018

Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.

Bercusson et. al., Blood., 2018

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites

Unger et. al., Front. Immunol., 2018

Synthetic mRNA expressed Cas13a mitigates RNA virus infections

Bawage et. al. , BioRxiv, 2018

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.

Weber et. al., Nat Commun., 2018

Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions upon epithelial differentiation.

Noethel et. al., Mol Biol Cell., 2018

GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells.

Chen et. al., Int J Cancer., 2018

Immunostimulatory guide RNAs mediate potent antiviral response

Cai et. al., BioRxiv, 2018

Membrane Fluidity Is Regulated Cell Non-autonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2.

Bodhicharla et. al., Genetics., 2018

Neurodevelopmental protein Musashi1 interacts with the Zika genome and promotes viral replication.

Chavali et. al., Science., 2017

Expression of AGPAT2, an enzyme involved in the glycerophospholipid / triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.

Triantafyllou et. al., Biochim Biophys Acta., 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler et. al., Cell., 2018

High molecular weight hyaluronic acid: a two-pronged protectant against infection of the urogenital tract?

Mowbray et. al., Clinical & Translational Immunology 2018

Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.

Li et. al., Oncogene., 201

Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.

Ringleb et. al., J Immunol., 2018

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini, Nat Immunol., 2018

The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2

Fuchs et. al., BioRxiv, 2018

Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity.

Shin et. al., Mol Ther Nucleic Acids., 2018

CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.

Taylor et. al., J Leukoc Biol., 2018

The 5T4 oncofetal glycoprotein does not act as a general organizer of the CXCL12 system in cancer cells.

Puchert et. al., Exp Cell Res., 2018

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells.

transfections in supplemental data

Xue et. al., Nat Mater., 2018

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.

Mueller et. al., J Biol Chem., 2018

Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma

Chortis et. al., Endocrinology, 2018

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

transfections in supplemental data

Anderson et. al., Nat Commun., 2018

Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms.

Leber et. al., Inflamm Bowel Dis. 2018

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.

Slater et. al., Virol J. 2018

Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection.

Herrera-Uribe et. al., Vet Res., 2018

Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction.

Bhosle et. al., Biomaterials. 2018

Involvement of the oncogene B-cell lymphoma 6 in the fusion and differentiation process of trophoblastic cells of the placenta.

Jasmer et. al., Oncotarget., 2017

Functional characterization of the protein kinase MK2 in the pathogenesis of Experimental autoimmune encephalomyelitis (EAE)
Gupta – 2017
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

Mathur et. al., Neuron., 2017

RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.

Egami et. al., J Cell Sci., 2017

Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages.

Lin et. al., Cell Syst., 2017

The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids

Devkota et. al., PLoS Genet., 2017

Long 3’UTR of Nurr1 mRNAs is targeted by miRNAs in mesencephalic dopamine neurons.

Pereira et. al., PLoS One., 2017

Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling.

Nishiyama et. al., Int Immunopharmacol., 2017

Dexamethasone-induced upregulation of CaV3.2 T-type Ca2+ channels in rat cardiac myocytes.

Falcón et. al., J Steroid Biochem Mol Biol., 2017

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

Van Opdenbosch et. al., Cell Rep., 2017

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.

Fujita et. al., Nat Commun., 2017

Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.

Ambrosio et. al., Oncogene. 2017

Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.

Thompson et. al., bioRxiv, 2017

Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase.

Chen et. al., Arterioscler Thromb Vasc Biol., 2017

The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat

Long et. al., Sci Rep., 2017

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.

Rübsam et. al., Nat Commun. 2017

Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses

Kim et. al., Adv Healthc Mater., 2017

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction

Smith et. al., Int J Biochem Cell Biol., 2017

The MAV_4644 dual-function channel protein with putative ADP-ribosyltransferase activity of Mycobacterium avium is required for virulence within host macrophages

Lewis – 2017


O’Reilly – 2017

Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation.

Drakouli et. al., FEBS J., 2017

Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection.
Ali et. al., Sci Rep., 2017
The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts.

McCormack et. al., Sci Rep., 2017

Kirschman – 2017
The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability.

Shah et. al., Nat Commun., 2017

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

Liszt et. al., Proc Natl Acad Sci U S A., 2017

Angiopoietin-like Protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

Ingerslev et. al., Mol Metab., 2017

Integrated analysis of miRNA expression in response to Salmonella  Typhimurium infection in pigs.
Herrera Uribe – 2017
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.

Brüser et. al., Sci Rep., 2017

The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma.

Kijewska et. al., Oncotarget., 2017

Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential.

Walsh et. al., Sci Rep., 2017

Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells.

Kirschman, Nucleic Acids Res., 2017

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

Armento et. al., Int J Oncol., 2017

Hmga2 translocation induced in skin tumorigenesis.

Li et. al., Oncotarget., 2017

FGF23 is synthesised locally by renal tubules and activates injuryprimed fibroblasts.

transfections in supplemental data

Smith et. al., Sci Rep., 2017

The role of microRNA-5196 in the pathogenesis of systemic sclerosis.

Ciechomska et. al., Eur J Clin Invest., 2017

Effects of hypnotic bromovalerylurea on microglial BV2 cells.

Kawasaki et. al., J Pharmacol Sci., 2017

HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors.

Kew et. al., J Mol Biochem., 2017

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.

Furtado et. al., JCI Insight., 2017

A p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of EBV-related B cell origin cancer cells via regulation of NF-κB.

Park et. al., Int J Oncol., 2017

Corneal stromal stem cells reduce corneal scarring by mediating neutrophil infiltration after wounding.

Hertsenberg et. al., PLoS ONE, 2017


Burai et. al., US Patent 20,170,050,967, 2017

Microglial complement receptor 3 regulates brainlevels through secreted proteolytic activity.

Czirr et. al., J Exp Med., 2017

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

Haneklaus et. al., JBC, 2017

Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia.

Chinthamani et. al., PLoS ONE, 2017

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.

Diamanti et. al., J Exp Med., 2017

Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial–mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms.

Rodríguez-Mateo et. al., Cell Death & Differentiation, 2017

Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites.

Muggiolu et. al., Sci Rep., 2017

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.

Mescher et. al., J Exp Med.,  2017

The dual role of asporin in breast cancer progression.

Simkova, Oncotarget., 2016

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures.

Morrison, J. Vis. Exp., 2016

Differential IL-1β secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability.

Hadadi, Sci Rep.,  2016

The p7 viroporin of the hepatitis C virus contributes to liver inflammation by stimulating production of Interleukin-1 β.

Farag et. al., Biochim Biophys Acta., 2016

Loss of the Tumor Suppressor NKX3.1 in Prostate Cancer Cells is Induced by Prostatitis Related Mitogens

Decker, J Clin Onc Exp Onc, 2016

Transkriptionsregulation der Pyruvatdehydrogenase – Kinase 4 (PDK4), einem zentralen Schalter des Glukosestoffwechsels, durch Zelladhäsion und onkogene Signalwege beim humanen Ovarialkarzinom
Schnitzer – 2016
Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.

Klingler, Biochim Biophys Acta., 2016

Early Intervention Stem Cell-Based Therapy (EISCBT) for Corneal Burns and Trauma

Funderburgh – 2016

IFN-ε protects primary macrophages against HIV infection.

Tasker, JCI Insight., 2016

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells.

Ciechomska, Sci Rep., 2016

GSK-3β controls NF-kappaB activity via IKKγ/NEMO.

Medunjanin, Sci Rep., 2016

Defining functional interactions during biogenesis of epithelial junctions

Erasmus, Nat Commun., 2016

Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.

Jung et. al., Sci Signal., 2016

Human Neural Progenitor Cells are Productively Infected by R5-tropic HIV-1: Opiate Interactions on Infection and Function Involve Cdk5 Signaling

JM Balinang – 2016


Donor dendritic cellderived exosomes promote allografttargeting immune response.

transfections in supplemental data

Liu et. al., J Clin Invest., 2016

Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease

Kadiyska – 2016

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.

Yan, Cell Rep, 2016

Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression.

Ellert-Miklaszewska et. al., Oncogene 2016

Extensive nuclear sphere generation in the human Alzheimer’s brain

Kolbe et. al., NeuroBiolAging, 2016

Ziros et. al., PLoS One., 2016

Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.

Machacek et. al., J Immunol., 2016

Analyse des signalinduzierten Verlusts des Tumorsuppressors NKX3.1 in Prostatitis und Prostatakarzinomzellen
Decker, 2016
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.

Martin-Almedina et. al., J Clin Invest. 2016

HIV-Infected Dendritic Cells Present Endogenous MHC Class II-Restricted Antigens to HIV-Specific CD4+ T Cells.

Coulon et. al., J Immunol., 2016

ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers
Madan et. al., Am J Cancer Re., 2016
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.

Kranz et. al., Nature. 2016

Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization.

Watanabe et. al., Proc Natl Acad Sci U S A., 2016

Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.

Shen et. al., Am J Pathol., 2016

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

Paijo et. al., PLoS Pathog., 2016

microRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

Griss et. al., J Infect Dis, 2016

Steroidogenesis in Steroid Related Cancers

Turgeman – 2016

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

Robertson et. al., PLoS Biol, 2016

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans

Ordelheide et. al., Molecular Metabolism, 2016

Histone demethylation and TLR8-dependent crosstalk in monocytes promotes trans-differentiation of fibroblasts in systemic sclerosis via Fra2.

Ciechomska, Arthritis Rheumatol, 2016

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.

Yuniati et. al., Oncotarget, 2016

Pathways of retinoid synthesis in mouse macrophages and bone marrow cells.

Niu et. al., J Leukoc Biol, 2016

p53 coordinates base excision repair to prevent genomic instability

Poletto, Nucleic Acids Res, 2016

Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with Influenza A virus

Pichulik, Eur J Immunol, 2015

Hypoxia Differentially Modulates the Genomic Stability of Clinical-Grade ADSCs and BM-MSCs in Long-Term Culture.

Bigot, Stem Cells, 2015

Drug Delivery Using Novel Biological and Synthetic Materials

Ito et. al., Biomed Res Int, 2015

Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.

Chen et. al., Sci Signal., 2015

The Comparative Utility of Viromer RED and Lipofectamine for Transient Gene Introduction into Glial Cells

Rao, Hindawi Publishing Group, BioMed Research International, 2015

Inhibition of adipogenic differentiation of human SGBS preadipocytes by androgen-regulated microRNA miR-375.

Kraus, Mol Cell Endocrinol., 2015

Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.

Rane, Br J Cancer, 2015

TRIM25 has a dual function in the p53/Mdm2 circuit

Zhang, Oncogene, 2015

Weber, 2015



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