Viromer® in myology / cardio-vascular research

Recent progress in genetics and continuous development of innovative therapeutics have made myology and cardio-vascular researches full-fledged disciplines within the medical and scientific field. Covering the study of muscle physiology, myogenesis, muscular and neuromuscular diseases, injuries, aging, sport-induced damages, it involves a very active work at the bench to better understand the functioning of skeletal, smooth, or cardiac muscle cells and the associated pathologies.

Transfection of these cells is an indispensable tool to understand molecular pathways underlying cells functions in healthy or pathological conditions. The Viromer® technology has provided so far very promising results for a broad spectrum of muscle cells, including primary cells, hard-to-transfect cardiomyocytes and myosarcoma cells. As model cell lines for cardio-vascular research, it should be also noticed good efficiency for HUVEC and HMVEC cells.

siRNA-mediated gene silencing

Up to 80-100% complete specific gene knock-downs have been achieved by transfecting siRNA into different kinds of myocytes including cardiomyocyts and HUVEC’s using Viromer® BLUE  or  Viromer® GREEN:

protein expression

in cardiomyocytes

in myoblasts


Viromer® BLUE | Viromer® GREEN | Viromer® RED | Viromer® YELLOW

transfection efficiency

< 30% | 30-50% | 50-80% | > 80%

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Type siRNA mRNA pDNA Data
C2C12               See data Publications
Cardiomyocytes, primary murine         See data Publications
Endothelial cells, primary human lymphatic         Publications
H9c2        See data
HDLEC primary human dermal lymphatic endothelial cells     Publication
HL-1    See data
HMVEC, primary human microvascular endothelial cells      Publication
HUVEC, primary human umbilical vein endothelial cells               See data Publication
Lymphatic endothelial cells, primary human         Publications
MPC, primary mouse muscle progenitor stem cells      Publication
Myoblasts, primary chicken embryo     See data
Myoblasts, primary human skeletal           See data Publications
Rhabdomyosarcoma RMS      See data
Smooth muscle cells, aortic, primary human            See data
Smooth muscle cells, bladder, primary human       
Smooth muscle cells, vascular, primary human       See data