Selective delivery into spleen using VIROMER® IN VIVO
Rapid and durable transfection of luciferase mRNA into spleen.
10μg mRNA formulated using specific Viromer®,mice seen from dorsal side.
Selective delivery into liver using Viromer® IN VIVO
Rapid and strong transfection of luciferase mRNA into liver.
Using 25 or 40μg of the mRNA:Viromer® complex, a preferred liver targeting is achieved. Expression in liver is very pronounced after 6h and still detectable after 24h.
(For mRNA delivery, particles of about 200nm were prepared. Carrier : Viromer® / Payload : mRNA coding for luciferase (Trilink). Complexes were injected i.v. into mice and expression was monitored over time using in vivo luminescense. © 2016, Lipocalyx)